BDBM15364 4-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol::CCT018159 analog 3

SMILES Cc1[nH]nc(c1-c1ccc2OCCOc2c1)-c1cc(Cl)c(O)cc1O

InChI Key InChIKey=RTIAXUYLACAMGU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15364   

TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15364(4-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5...)
Affinity DataIC50:  210nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine kinase(Caulobacter vibrioides)
Williams College

Curated by ChEMBL
LigandPNGBDBM15364(4-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVirulence sensor histidine kinase PhoQ(Salmonella typhimurium (strain LT2 / SGSC1412 / AT...)
Williams College

Curated by ChEMBL
LigandPNGBDBM15364(4-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of recombinant Salmonella typhimurium N-terminal His6-SUMO-tagged DHp-catalytic domain PhoQ (257 to 487 residues) autophosphorylation expr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed