BDBM15581 CHEMBL8706::CLG::CLORGILINE::Clorgyline::N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine::US8633208, Clorgyline::US9603833, Clorgyline::[3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine
SMILES CN(CCCOc1ccc(Cl)cc1Cl)CC#C
InChI Key InChIKey=BTFHLQRNAMSNLC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 222 hits for monomerid = 15581
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Soochow University
Curated by ChEMBL
Soochow University
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Inhibition of radioligand binding to sigma1 receptor in C57BL/6 mouse brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Medical College Of Georgia
Curated by PDSP Ki Database
Medical College Of Georgia
Curated by PDSP Ki Database
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Irreversible inhibition of recombinant human MAO-A expressed in baculovirus infected BT1 cells using p-tyramine as substrate by Lineweaver-Burk plot ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Reversible inhibition of recombinant human MAOA expressed in Pichia pastoris using varying levels of kynuramine as substrate measured after 5 mins by...More data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Inhibition of bovine brain MAOA using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorome...More data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Inhibitory activity against monoamine oxidase A in isolated bovine brain mitochondriaMore data for this Ligand-Target Pair
Affinity DataKi: 54nM ΔG°: -10.3kcal/molepH: 7.4 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically using kinuramine as substrates. Fluorimetric measurements were recorded with a Perk...More data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Inhibition of bovine brain mitochondrial MAO-A by fluorometric assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataKi: 220nMAssay Description:Irreversible inhibition of recombinant human MAOA expressed in Pichia pastoris using varying levels of kynuramine as substrate measured after 5 mins ...More data for this Ligand-Target Pair
Affinity DataKi: 505nMAssay Description:Inhibition of radioligand binding to sigma2 receptor in C57BL/6 mouse brain membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
University Of Turku
Curated by PDSP Ki Database
University Of Turku
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
University Of Turku
Curated by PDSP Ki Database
University Of Turku
Curated by PDSP Ki Database
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Hacettepe University
Curated by ChEMBL
Hacettepe University
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of MAO-A in rat liver homogenate after 60 mins by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Mechanism based inhibition of rat cytochrome P450 CYP2B1 measured by 7-EFC O-deethylation activityMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Hacettepe University
Curated by ChEMBL
Hacettepe University
Curated by ChEMBL
Affinity DataKi: 5.60E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate after 60 mins by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 5.80E+4nMAssay Description:Inhibition of bovine brain mitochondrial MAO-B by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.80E+4nMAssay Description:Inhibition of bovine brain MAOB using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorome...More data for this Ligand-Target Pair
Affinity DataKi: 5.80E+4nMAssay Description:MAO A and MAO B activities were determined spectrophotometrically using kinuramine as substrates. Fluorimetric measurements were recorded with a Perk...More data for this Ligand-Target Pair
Affinity DataKi: 5.80E+4nMAssay Description:Inhibitory activity against monoamine oxidase B in isolated bovine brain mitochondriaMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant MAO-A using pargyline as incubated for 20 mins measuring increase in emission signal at 310 nm multimode plate reader...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of human recombinant MAO-B by multimode plate reader assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant MAO-A by multimode plate reader assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of human MAO-A using p-tyramine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human full length recombinant MAO-A expressed in insect cells using kynuramine as substrateMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of MAO-A (unknown origin) expressed in mouse GL26 cells using 14C 5-hydroxytryptamine as substrate pre-incubated for 20 mins followed by s...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 8.87E+3nMAssay Description:Inhibition of human recombinant MAO-B incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant MAOA using kynuramine substrate incubated for 20 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of recombinant human MAO-B using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured over 15 mins by ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 7.65E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using benzylamine as substrate preincubated for 1 h...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using tyramine as substrate preincubated for 1 hr f...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 4.19E+3nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human MAOA using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 6.34E+4nMAssay Description:Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decrease in H2O2...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant microsomal MAOA expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decre...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MAO-A (unknown origin) using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate by MAO-Glo assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human microsomal MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected insect BTI-TN-5B1-4 cells assessed as p-tyramine conversion to H2O...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Nanyang Normal University
Curated by ChEMBL
Nanyang Normal University
Curated by ChEMBL
Affinity DataIC50: 6.14E+4nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in baculovirus-infected insect BTI-TN-5B1-4 cells assessed as p-tyramine conversion to H2O...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Padova
Curated by ChEMBL
University Of Padova
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant MAOA using kynuramine as substrate incubated for 10 mins by UPLC-ESI-MS/MS analysisMore data for this Ligand-Target Pair