BDBM163642 Methyl 2amino5[(3chloro4methylphenyl)carbamoyl]4methylthiophene3carboxylate (Inh 7)::US9334288, 3

SMILES COC(=O)c1c(N)sc(C(=O)Nc2ccc(C)c(Cl)c2)c1C

InChI Key InChIKey=BFKWJRPARVBAGW-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 163642   

TargetBeta-glucuronidase(Escherichia coli (Enterobacteria))
University of North Carolina At Chapel Hill

LigandPNGBDBM163642(Methyl 2amino5[(3chloro4methylphenyl)carbamoyl]4me...)
Affinity DataKi:  1.90E+3nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163642(Methyl 2amino5[(3chloro4methylphenyl)carbamoyl]4me...)
Affinity DataIC50:  1.69E+3nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163642(Methyl 2amino5[(3chloro4methylphenyl)carbamoyl]4me...)
Affinity DataIC50:  1.62E+3nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent