BDBM173348 US10323032, Example 66::US9096596, 66::US9604982, Example 66

SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(F)c(c1Cl)C(F)(F)F)nc(C)nc2-c1ccn[nH]1

InChI Key

Data  5 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 173348   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US10323032, Example 66 | US9096596, 66 | US9604982...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US10323032, Example 66 | US9096596, 66 | US9604982...)
Affinity DataKi:  50.1nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US10323032, Example 66 | US9096596, 66 | US9604982...)
Affinity DataKi:  50.1nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US10323032, Example 66 | US9096596, 66 | US9604982...)
Affinity DataKi:  50.1nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US10323032, Example 66 | US9096596, 66 | US9604982...)
Affinity DataKi:  50.1nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In DepthDetails US Patent