BDBM17944 Renin nonpeptide inhibitor, 4::methyl N-[(3R)-1-[(5S,6S,8S)-5-amino-8-(butylcarbamoyl)-6-hydroxy-3,3-dimethyl-8-(propan-2-yl)octanoyl]-1,2,3,4-tetrahydroquinolin-3-yl]carbamate

SMILES CCCCNC(=O)[C@@H](C[C@H](O)[C@@H](N)CC(C)(C)CC(=O)N1C[C@@H](Cc2ccccc12)NC(=O)OC)C(C)C

InChI Key InChIKey=UBIZUKGLAHGVAL-FVEXOFTDSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 17944   

TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17944(Renin nonpeptide inhibitor, 4 | methyl N-[(3R)-1-[...)
Affinity DataIC50:  0.5nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17944(Renin nonpeptide inhibitor, 4 | methyl N-[(3R)-1-[...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
Novartis Pharmaceuticals

LigandPNGBDBM17944(Renin nonpeptide inhibitor, 4 | methyl N-[(3R)-1-[...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed