BDBM181010 US9133197, 1
SMILES Cn1c(nc2c(N)nc(CCCCO)nc12)-n1nccn1
InChI Key InChIKey=LXKQSSJIYWOEPP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 181010
Affinity DataKi: 51nM ΔG°: -9.94kcal/molepH: 7.4 T: 2°CAssay Description:Competition binding experiments have been performed incubating membranes from CHO-K1 cells stably transfected with the human adenosine A1 receptor (c...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Sigma-Tau Industrie Farmaceutiche Riunite
US Patent
Sigma-Tau Industrie Farmaceutiche Riunite
US Patent
Affinity DataKi: 53nMpH: 7.4Assay Description:The protein concentration of membrane suspension was determined using the Bradford method (Pierce, Rockford, Ill., USA) with bovine albumin as standa...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Sigma-Tau Industrie Farmaceutiche Riunite
US Patent
Sigma-Tau Industrie Farmaceutiche Riunite
US Patent
Affinity DataKi: 53nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in HEK293 cells after 1 hr by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO-K1 cells after 60 minsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Sigma-Tau Industrie Farmaceutiche Riunite
US Patent
Sigma-Tau Industrie Farmaceutiche Riunite
US Patent
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at human adenosine A2A receptor expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP accumulation incubated for ...More data for this Ligand-Target Pair