BDBM18137 AMP::CHEMBL752::US11185100, TABLE 7.3::[(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;hydrate::adenosine 5 -monophosphate::{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Key InChIKey=UDMBCSSLTHHNCD-KQYNXXCUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 46 hits for monomerid = 18137
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKi: 0.230nM Kd: 1.13nM Koff: 4.43E+6s-1Assay Description:Association rate constant for the interaction between inhibitor and HIV-1 proteaseMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
TargetTransmembrane and immunoglobulin domain-containing 3(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
Affinity DataKi: 1.92E+4nMAssay Description:Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+4nMAssay Description:Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
Affinity DataKi: 8.00E+4nMAssay Description:Inhibitory activity against rat adenylate kinase II was determined in the presence of AMPMore data for this Ligand-Target Pair
Affinity DataKi: 8.00E+4nM ΔG°: -5.59kcal/mole IC50: 8.00E+5nMpH: 7.5 T: 25°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
Affinity DataKi: 4.50E+5nMAssay Description:Inhibition of inosine monophosphate dehydrogenase in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 5.80E+5nMAssay Description:Inhibitory activity against rat Adenylate kinase M isoenzyme in the presence of AMPMore data for this Ligand-Target Pair
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory
Curated by ChEMBL
University Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 6.30E+6nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 800nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataEC50: 1.52E+3nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKd: 3.70E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory
Curated by ChEMBL
University Chemical Laboratory
Curated by ChEMBL
Affinity DataKd: >5.00E+6nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coup...More data for this Ligand-Target Pair
Affinity DataEC50: 1.73E+4nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMore data for this Ligand-Target Pair
Affinity DataEC50: 7.20E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Affinity DataEC50: 7.20E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Affinity DataKd: 1.20E+5nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 resi...More data for this Ligand-Target Pair
Affinity DataKd: 3.70E+5nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged non-autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green dye based spectrop...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataEC50: 1.40E+3nMAssay Description:Inhibition of protein kinase C epsilon expressed in Sf-9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human liver FBP1 incubated for 5 mins by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate by malachite green dye based a...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) using FBP as substrate in presence of PGI and G6PDH by spectrophotometric me...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of p60c-src expressed in chick embryo fibroblastMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isom...More data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluc...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of FBPase in human liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKon: 0.00488M-1s-1Assay Description:Association rate constant for the interaction between inhibitor and HIV-1 proteaseMore data for this Ligand-Target Pair
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T](Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.32E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry methodMore data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair