BDBM18244 6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine::Piritrexim analogue, 56

SMILES COc1ccc(I)c(Cc2cnc3nc(N)nc(N)c3c2C)c1

InChI Key InChIKey=JLYBTCUUMJBPSE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18244   

TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

LigandPNGBDBM18244(6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  3.80nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

LigandPNGBDBM18244(6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  4nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

LigandPNGBDBM18244(6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  1.80nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

LigandPNGBDBM18244(6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  5.80nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed