BDBM18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US20230339856, Compound NB-DNJ::US9181184, 5

SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

InChI Key InChIKey=UQRORFVVSGFNRO-UTINFBMNSA-N

Data  5 KI  56 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18355   

TargetSucrase-isomaltase(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of wild type C57BL/6 mouse small intestinal sucrase/isomaltase using sucrose as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid/Non-lysosomal glucosylceramidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of recombinant human GBA1More data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of rat liver lysosomal alpha-glucosidase using p-nitrophenyl alpha-D-glucopyranoside as substrate by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  1.58E+5nMAssay Description:Inhibition of recombinant human GAA by UV-visible spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed