BDBM217366 Pep2-8::TVFTSWEEYLDWV

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(N)=O

InChI Key

Data  1 IC50  3 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 217366   

TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Genentech

LigandPNGBDBM217366(Pep2-8 | TVFTSWEEYLDWV)
Affinity DataIC50:  1.40E+3nMAssay Description:For the peptide affinity determinations, biotinylated PCSK9 was immobilized to NeutrAvidin-coated MaxiSorp Immuno-Plates and incubated with a mixture...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Genentech

LigandPNGBDBM217366(Pep2-8 | TVFTSWEEYLDWV)
Affinity DataKd:  700nMAssay Description:Binding affinity to recombinant human C-terminal His8-tagged PCSK9 expressed in Chinese hamster ovary cells by biolayer interferometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Genentech

LigandPNGBDBM217366(Pep2-8 | TVFTSWEEYLDWV)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDL uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Genentech

LigandPNGBDBM217366(Pep2-8 | TVFTSWEEYLDWV)
Affinity DataKd:  700nMAssay Description:Binding affinity to human PCSK9More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Genentech

LigandPNGBDBM217366(Pep2-8 | TVFTSWEEYLDWV)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as restoration of LDLRMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Genentech

LigandPNGBDBM217366(Pep2-8 | TVFTSWEEYLDWV)
Affinity DataKd:  9.70E+3nMAssay Description:Binding affinity to human PCSK9 by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed