BDBM23620 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol::CHEMBL932::Dipyridamine::Dipyridamole::Dipyudamine::MLS000028420::Persantine::SMR000058382::cid_3108

SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO

InChI Key InChIKey=IZEKFCXSFNUWAM-UHFFFAOYSA-N

Data  8 KI  34 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23620   

TargetEquilibrative nucleoside transporter 1(Homo sapiens (Human))
University of Tennessee Health Science Center

LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  8.18nM ΔG°:  -10.9kcal/mole IC50:  145nMpH: 7.4 T: 2°CAssay Description:The compounds were tested to determine their ENT1 nucleoside transporter binding ability by a flow cytometric assay using human leukemia K562 cells i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEquilibrative nucleoside transporter 1(Homo sapiens (Human))
University of Tennessee Health Science Center

LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  8.80nMAssay Description:Displacement of 5-(SAENTA)-X8-fluorescein from K562 cell nucleoside transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Tokyo Dental College

Curated by PDSP Ki Database
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  87.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  125nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Tokyo Dental College

Curated by PDSP Ki Database
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  162nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  400nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  600nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank