BDBM26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34
SMILES CCN(CCCOc1ccc2c(c1)ncnc2Nc3cc(n[nH]3)CC(=O)Nc4cccc(c4)F)CCO
InChI Key InChIKey=QYZOGCMHVIGURT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 821 hits for monomerid = 26300
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2.80nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.90nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 4.40nMAssay Description:Binding constant for AURKC kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 4.40nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 4.40nMAssay Description:Binding constant for full-length AURKCMore data for this Ligand-Target Pair
Affinity DataKd: 4.60nMAssay Description:Binding constant for AURKB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.20nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 7.20nMAssay Description:Binding constant for AURKB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.90nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.90nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8.20nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8.20nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8.20nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding affinity to human KIT incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylationMore data for this Ligand-Target Pair
Affinity DataKd: 34nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 38nMAssay Description:Binding constant for PDGFRA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 38nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 38nMAssay Description:Binding constant for PDGFRA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 41nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 41nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 41nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 43nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 43nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [N841I](Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 43nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding constant for EPHB6 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 80nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 80nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T](Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 80nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 97nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T](Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 120nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 120nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for RET(V804L) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 140nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair