BDBM307569 1-(2-((2R,4R)-4-((4-(2,2- difluoroethoxy)pyridin-2-yl)amino)-2- methylpyrrolidine-1- carbonyl)phenyl)cyclopropanecarbonitrile::US10150751, Example 2

SMILES C[C@@H]1C[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)Nc1cc(OCC(F)F)ccn1

InChI Key InChIKey=NYNWLNOPIWKERJ-HZPDHXFCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307569   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307569(1-(2-((2R,4R)-4-((4-(2,2- difluoroethoxy)pyridin-2...)
Affinity DataIC50:  1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307569(1-(2-((2R,4R)-4-((4-(2,2- difluoroethoxy)pyridin-2...)
Affinity DataIC50:  65.1nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent