BDBM31197 CHEMBL211045::Nutlin-3::med.21724, Compound 186
SMILES COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
InChI Key InChIKey=BDUHCSBCVGXTJM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 31197
Affinity DataKi: 30nMAssay Description:Inhibition of 5'--FAM-LTFEHYWAQLTS peptide binding to N-terminal domain human MDM2 (1 to 118 residues) expressed in Escherichia coli BL21(DE3) measur...More data for this Ligand-Target Pair
Affinity DataKi: 36nM ΔG°: -10.1kcal/molepH: 7.5 T: 23°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 36nM ΔG°: -10.1kcal/molepH: 7.5 T: 23°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
Affinity DataKi: 280nMAssay Description:Inhibition of MDM2 (unknown origin) using peptide as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to MDMX (unknown origin) by using (FITC)-labeled p53 peptide based fluorescence polarization competitive assayMore data for this Ligand-Target Pair
Affinity DataKd: 240nMAssay Description:Binding affinity to MDM2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Binding affinity to human MDM2 expressed in Escherichia coli expression system by using (FITC)-labeled p53 peptide based fluorescence polarization co...More data for this Ligand-Target Pair
Affinity DataKd: 263nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of GST-tagged MDM2 binding to p53 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 105nMAssay Description:Binding affinity to MDM2 in human U87MG cells assessed as inhibition of MDM2/p53 protein interaction after 10 mins by quantitative sandwich immuno as...More data for this Ligand-Target Pair
Affinity DataEC50: 3.69E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair