BDBM412127 US10392402, Compound ID 5::US10807966, Compound 25

SMILES COc1cccc(CNC(=O)Nc2cc([nH]n2)-c2ccncc2)c1

InChI Key InChIKey=PGAUIFVQAJTKKJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 412127   

TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Drug Development

US Patent
LigandPNGBDBM412127(US10392402, Compound ID 5 | US10807966, Compound 2...)
Affinity DataIC50:  73nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Drug Development

US Patent
LigandPNGBDBM412127(US10392402, Compound ID 5 | US10807966, Compound 2...)
Affinity DataIC50:  16.1nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Drug Development

US Patent
LigandPNGBDBM412127(US10392402, Compound ID 5 | US10807966, Compound 2...)
Affinity DataIC50:  28.7nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Drug Development

US Patent
LigandPNGBDBM412127(US10392402, Compound ID 5 | US10807966, Compound 2...)
Affinity DataIC50:  16.1nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Drug Development

US Patent
LigandPNGBDBM412127(US10392402, Compound ID 5 | US10807966, Compound 2...)
Affinity DataIC50:  130nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Drug Development

US Patent
LigandPNGBDBM412127(US10392402, Compound ID 5 | US10807966, Compound 2...)
Affinity DataIC50:  73nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent