BDBM416664 (2S)-2-[3-(3-Fluoroazetidin-1-yl)-5-methoxy-phenyl]-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-[3-(3-Fluoroazetidin-1-yl)-5-methoxy-phenyl]-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US10323028, Example 10(a)::US10323028, Example 10(b)::US10981904, Example 10(a)
SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(c1)N1CC(F)C1
InChI Key InChIKey=ZHRNCBVUEKDLAI-OXQOHEQNSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 416664
Affinity DataIC50: 34.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 34.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Affinity DataIC50: 72.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair