BDBM416686 (2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US10323028, Example 21(a)::US10981904, Example 44

SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1

InChI Key InChIKey=MCWGAWNVXRUZFM-KDOFPFPSSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 416686   

TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM416686((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Affinity DataIC50:  20nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM416686((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Affinity DataIC50:  48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM416686((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Affinity DataIC50:  48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM416686((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Affinity DataIC50:  48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent