BDBM4304 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide::CHEMBL56731::cid_5328771::tyrphostin 1

SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O

InChI Key InChIKey=HKHOVJYOELRGMV-XYOKQWHBSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4304   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(RAT)
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  9.00E+4nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of ERBB2 receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed