BDBM447585 2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)quinoxalin-2-yl)piperazin-1-yl)ethyl acetate::US10689362, Example 74

SMILES COc1ccc(COc2ccc(Nc3ccc4ncc(nc4c3C#N)N3CCN(CCOC(C)=O)CC3)cc2OC)cn1

InChI Key InChIKey=IAVBANAUIJFOJN-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 447585   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447585(2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3...)
Affinity DataKi:  27.5nMAssay Description:c-KIT: Inhibition of c-KIT kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 20 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447585(2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3...)
Affinity DataIC50: >1.00E+6nMAssay Description:PDGFRβ: Inhibition of PDGFRβ kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447585(2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3...)
Affinity DataIC50: >1.00E+6nMAssay Description:FLT3: Inhibition of FLT3 kinase activity by a test compound disclosed herein was estimated by radiometric assay. Standard assay conditions were 5 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM447585(2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3...)
Affinity DataIC50:  27.5nMAssay Description:CSF-1R: Inhibition of CSF-1R kinase activity by a test compound disclosed herein was estimated by AlphaScreen (PerkinElmer). Standard assay condition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent