BDBM454858 US10730870, Example 21::US11512083, Example 21

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)Cc2ccccc2)C(C)(C)C)cc1

InChI Key InChIKey=GAUPKVQHAPDXDP-ONBPZOJHSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 454858   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  5.69E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  392nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  1.49E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  1.49E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  5.69E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  392nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataKd:  450nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VCB (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed