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Found 4 Enz. Inhib. hit(s) with Target = 'von Hippel-Lindau disease tumor suppressor' and Ligand = 'BDBM454858'
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  392nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  1.49E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataIC50:  5.69E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM454858(US10730870, Example 21 | US11512083, Example 21)
Affinity DataKd:  450nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VCB (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed