BDBM455316 US10730875, Compound 17
SMILES CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)cn12
InChI Key InChIKey=KVDVPIKOIQBWCY-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 455316
Affinity DataIC50: <500nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:To assay JAK1 inhibition, 2 μL of IL-6 diluted at 400 ng/mL (4×) in HBSS containing 0.1% BSA was added to the treated cells. The cells were then...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair