BDBM458966 (4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(2-fluorophenyl)methanone::US10759794, Example 4

SMILES Fc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1

InChI Key InChIKey=NABAWQRCDXXOMF-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 458966   

TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458966((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...)
Affinity DataIC50:  9.70nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458966((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...)
Affinity DataIC50:  15nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458966((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of human TASK-1 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at +40mV holding potential by two-electrode ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458966((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...)
Affinity DataIC50:  46nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458966((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...)
Affinity DataIC50:  172nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB