BDBM490306 US10968215, Compound 183::US10968215, Compound 184::US10968215, Compound 185

SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)OCc2nccs2)c1C)-c1ccn[nH]1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 490306   

LigandPNGBDBM490306(US10968215, Compound 183 | US10968215, Compound 18...)
Affinity DataIC50: <100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM490306(US10968215, Compound 183 | US10968215, Compound 18...)
Affinity DataIC50: <100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM490306(US10968215, Compound 183 | US10968215, Compound 18...)
Affinity DataIC50: <100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent