BDBM50034928 5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23867
SMILES Cc1c(CNc2cccc3ccccc23)cnc2nc(N)nc(N)c12
InChI Key InChIKey=NKRNRLZUZGBLHL-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50034928
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
Affinity DataIC50: 573nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis cariniiMore data for this Ligand-Target Pair
Affinity DataIC50: 29.6nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 573nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute
Curated by ChEMBL
Lindsley F. Kimball Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.810nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute
Curated by ChEMBL
Lindsley F. Kimball Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 14.5nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 29.6nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair