BDBM50034928 5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23867

SMILES Cc1c(CNc2cccc3ccccc23)cnc2nc(N)nc(N)c12

InChI Key InChIKey=NKRNRLZUZGBLHL-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50034928   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034928(5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034928(5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3...)
Affinity DataIC50:  573nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034928(5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3...)
Affinity DataIC50:  29.6nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034928(5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3...)
Affinity DataIC50:  573nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034928(5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3...)
Affinity DataIC50:  14.5nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034928(5-Methyl-6-(naphthalen-1-ylaminomethyl)-pyrido[2,3...)
Affinity DataIC50:  29.6nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed