BDBM50058914 CHEMBL303597::[6-(4-Carbamimidoyl-benzoylamino)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid

SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)N(CC(O)=O)CCc2c1

InChI Key InChIKey=GHDCUSYVABYCFY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50058914   

TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058914(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  76nMAssay Description:Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058914(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058914(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 1% bovine serum albumin (BSA)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058914(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50058914(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed