BDBM50079575 CHEMBL3417586

SMILES [H][C@]12C[C@@]1([H])C(=NNC2=O)c1ccc(OCCCN2CCC[C@H]2C)cc1

InChI Key InChIKey=FJHKZEVPGYADEG-XYPHTWIQSA-N

Data  7 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50079575   

TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi:  14nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of alpha-2C adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human H4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human H2RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human H1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataEC50:  0.600nMAssay Description:Inverse agonist activity at human H3R expressed in CHO cells assessed as inhibition of RAMH-induced [35S]GTPgammaS binding relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Teva Global R & D.

Curated by ChEMBL
LigandPNGBDBM50079575(CHEMBL3417586)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed