BDBM50095601 CHEMBL25405::[4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-chloro-phenyl)-methanone

SMILES Clc1ccc(cc1)C(=O)c1ccc(OC2CN3CCC2CC3)cc1

InChI Key InChIKey=PXFAACCCJKQJNK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50095601   

TargetLanosterol synthase(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 58nMAssay Description:In vitro percent inhibitory activity of the compound against rat microsomal OSC enzyme at 1 uM concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 35nMAssay Description:Compound was tested for its inhibition against human OSC enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 58nMAssay Description:Concentration for the inhibition of rat microsomal oxidosqualene cyclase-lanosterol synthase (OSC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 22nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Trypanosoma bruceiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 160nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 92nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 400nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed