BDBM50123449 CHEMBL437996::Chloropeptin II::ISOCOMPLESTATIN

SMILES [H][C@@]12NC(=O)[C@H](NC(=O)[C@@H](Cc3c[nH]c4cc(ccc34)-c3cc1cc(Oc1ccc(C[C@H](N(C)C(=O)[C@H](NC2=O)c2cc(Cl)c(O)c(Cl)c2)C(=O)N[C@@H](C(O)=O)c2ccc(O)cc2)cc1)c3O)NC(=O)C(=O)c1cc(Cl)c(O)c(Cl)c1)c1cc(Cl)c(O)c(Cl)c1

InChI Key InChIKey=JJGZGELTZPACID-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50123449   

TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV1 integrase 3' processing/strand transfer coupled activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  500nMAssay Description:Inhibition of disintegration activity of HIV1 intact integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of integration activity of HIV1 intact integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  500nMAssay Description:Inhibition of disintegration activity of HIV1 integrase catalytic core domain (50 to 212)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed