BDBM50175157 CHEMBL371932::N-(bis(4-fluorophenyl)methyl)-8-butyl-8-aza-bicyclo[3.2.1]octan-3-amine

SMILES CCCCN1C2CCC1CC(C2)NC(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=YGVRYGYKGFIQTL-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50175157   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50175157(CHEMBL371932 | N-(bis(4-fluorophenyl)methyl)-8-but...)
Affinity DataKi:  21.5nMAssay Description:Displacement of [3H]WIN-from DAT in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50175157(CHEMBL371932 | N-(bis(4-fluorophenyl)methyl)-8-but...)
Affinity DataKi:  24nMAssay Description:Inhibition of [3H]WIN5428 uptake at wild type human DAT expressed in African green monkey COS7 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50175157(CHEMBL371932 | N-(bis(4-fluorophenyl)methyl)-8-but...)
Affinity DataKi:  62nMAssay Description:Inhibition of [3H]DA uptake at wild type human DAT expressed in African green monkey COS7 cells after 5 mins by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50175157(CHEMBL371932 | N-(bis(4-fluorophenyl)methyl)-8-but...)
Affinity DataKi:  454nMAssay Description:Displacement of [3H]pirenzepine from Muscarinic receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50175157(CHEMBL371932 | N-(bis(4-fluorophenyl)methyl)-8-but...)
Affinity DataKi:  2.64E+3nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50175157(CHEMBL371932 | N-(bis(4-fluorophenyl)methyl)-8-but...)
Affinity DataKi:  2.92E+3nMAssay Description:Displacement of [3H]nisoxetine from NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed