BDBM50177180 3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrrolidine-2,5-dione::CHEMBL372408

SMILES Oc1cc(N2CCN(CC2)c2ccc(O)cc2)c(O)n1-c1ccccc1

InChI Key InChIKey=YIAYJWOHRNVYRN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50177180   

TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against cytosolic malic enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  220nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed