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Found 71 Enz. Inhib. hit(s) with Target = 'NADP-dependent malic enzyme'
TargetNADP-dependent malic enzyme(Escherichia coli (strain K12))
Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50338502(5-O-phosphate-1-N-(4'-(4''-methoxyhenyl))-[1',2',3...)
Affinity DataKi:  5.70E+4nMAssay Description:Inhibition of Escherichia coli K-12 recombinant NAD-dependent malic enzyme by Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405810(CHEMBL5284610)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405814(CHEMBL5285899)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405806(CHEMBL5275653)
Affinity DataIC50:  80nMAssay Description:In vitro inhibitory activity against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405807(CHEMBL5287773)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405803(CHEMBL5284469)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405805(CHEMBL5289840)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405801(CHEMBL5289950)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405802(CHEMBL5278951)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405811(CHEMBL5277536)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405804(CHEMBL5279230)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405813(CHEMBL5288731)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405808(CHEMBL5279096)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405818(CHEMBL5273550)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against cytosolic malic enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405808(CHEMBL5279096)
Affinity DataIC50:  150nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405817(CHEMBL5267542)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405811(CHEMBL5277536)
Affinity DataIC50:  150nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405824(CHEMBL5279589)
Affinity DataIC50:  160nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405806(CHEMBL5275653)
Affinity DataIC50:  170nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405803(CHEMBL5284469)
Affinity DataIC50:  180nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405807(CHEMBL5287773)
Affinity DataIC50:  180nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405815(CHEMBL5278596)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405802(CHEMBL5278951)
Affinity DataIC50:  200nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405809(CHEMBL5283020)
Affinity DataIC50:  210nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50177180(3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrr...)
Affinity DataIC50:  220nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405800(CHEMBL5267207)
Affinity DataIC50:  220nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405812(CHEMBL5281297)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405825(CHEMBL5286488)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405826(CHEMBL5290463)
Affinity DataIC50:  250nMAssay Description:In vitro inhibitory activity against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405805(CHEMBL5289840)
Affinity DataIC50:  270nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405822(CHEMBL5274945)
Affinity DataIC50:  310nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405809(CHEMBL5283020)
Affinity DataIC50:  330nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405801(CHEMBL5289950)
Affinity DataIC50:  340nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405823(CHEMBL5286064)
Affinity DataIC50:  360nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405816(CHEMBL5291081)
Affinity DataIC50:  390nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405819(CHEMBL5282439)
Affinity DataIC50:  410nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405810(CHEMBL5284610)
Affinity DataIC50:  420nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50177175(1-benzyl-3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-p...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against cytosolic malic enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405820(CHEMBL5270965)
Affinity DataIC50:  470nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50177184(1-(3-chloro-4-methylphenyl)3-(4-(4-hydroxyphenyl)p...)
Affinity DataIC50:  560nMAssay Description:Inhibitory activity against cytosolic malic enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405821(CHEMBL5281258)
Affinity DataIC50:  580nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405804(CHEMBL5279230)
Affinity DataIC50:  630nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405798(CHEMBL5218866)
Affinity DataIC50:  900nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405798(CHEMBL5218866)
Affinity DataIC50:  940nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405818(CHEMBL5273550)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of spermidine synthase activity was evaluatedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405825(CHEMBL5286488)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405822(CHEMBL5274945)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of spermidine synthase activity was evaluatedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNADP-dependent malic enzyme(Homo sapiens (Human))
Cytrx Laboratories

Curated by ChEMBL
LigandPNGBDBM50405816(CHEMBL5291081)
Affinity DataIC50:  1.31E+3nMAssay Description:50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
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