BDBM50188739 1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-m-tolylurea::CHEMBL213507

SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1

InChI Key InChIKey=JBIAJPDELARJKZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50188739   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188739(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Affinity DataIC50:  146nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188739(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Affinity DataIC50:  61nMAssay Description:Inhibition of KDR at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188739(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Affinity DataIC50:  61nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188739(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Affinity DataIC50:  146nMAssay Description:Inhibition of KDR phosphorylation in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188739(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Affinity DataIC50:  86nMAssay Description:Inhibition of cKit at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188739(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of FLT1 at 1mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed