BDBM50210283 1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-m-tolylurea::CHEMBL223220

SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1

InChI Key InChIKey=NEJMZWVLFRWQSG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50210283   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210283(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human KDR kinase by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210283(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  44nMAssay Description:Inhibition of FLT1 at 1mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210283(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  64nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210283(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  96nMAssay Description:Inhibition of cKit at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210283(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  51nMAssay Description:Inhibition of KDR at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed