BDBM50241313 (5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2(5H)-one::(R)-(+)-Thiolactomycin::(R)-4-Hydroxy-3,5-dimethyl-5-((E)-2-methyl-buta-1,3-dienyl)-5H-thiophen-2-one::(R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one::5R-Thiolactomycin::CHEMBL399043::TLM analog, 1
SMILES CC1C(=O)S[C@](C)(\C=C(/C)C=C)C1=O
InChI Key InChIKey=IKJRVRCIDNWYPZ-CXQVHHQOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50241313
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery
Institute For Chemical Biology & Drug Discovery
Affinity DataKi: 1.90E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery
Institute For Chemical Biology & Drug Discovery
Affinity DataKi: 1.75E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 3(Mycobacterium tuberculosis)
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against KasA from Mycobacterium tuberculosis H37RvMore data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 3(Mycobacterium tuberculosis)
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibitory activity against FabH from Mycobacterium tuberculosis H37RvMore data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Mycobacterium tuberculosis)
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against KasB from Mycobacterium tuberculosis H37RvMore data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against human FAS1More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Staphylococcus aureus)
Colorado State University
Curated by ChEMBL
Colorado State University
Curated by ChEMBL
Affinity DataKd: 1.07E+5nMAssay Description:Binding affinity to Staphylococcus aureus wild type FabF expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence qu...More data for this Ligand-Target Pair
Affinity DataIC50: >9.51E+5nMAssay Description:Inhibition of FASN in rat liverMore data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 3(Mycobacterium tuberculosis)
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis FabHMore data for this Ligand-Target Pair
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Russian Academy Of Sciences
Curated by ChEMBL
Russian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 9.98E+4nMAssay Description:Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cellsMore data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cellsMore data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Staphylococcus aureus)
Colorado State University
Curated by ChEMBL
Colorado State University
Curated by ChEMBL
Affinity DataKd: 8.80E+4nMAssay Description:Binding affinity to Staphylococcus aureus FabF C165Q mutant expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Staphylococcus aureus)
Colorado State University
Curated by ChEMBL
Colorado State University
Curated by ChEMBL
Affinity DataKd: 1.07E+5nMAssay Description:Binding affinity to Staphylococcus aureus wild type FabF expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence qu...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Staphylococcus aureus)
Colorado State University
Curated by ChEMBL
Colorado State University
Curated by ChEMBL
Affinity DataKd: 8.80E+4nMAssay Description:Binding affinity to Staphylococcus aureus FabF C165Q mutant expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 3(Escherichia coli)
Konkuk University
Curated by ChEMBL
Konkuk University
Curated by ChEMBL
Affinity DataKd: 1.21E+5nMAssay Description:Binding affinity to Escherichia coli K12 KAS 3 expressed in Escherichia coli BL21 by fluorescence quenching analysisMore data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis)
Institute For Chemical Biology & Drug Discovery
Institute For Chemical Biology & Drug Discovery
Affinity DataKd: 2.26E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
National Institute Of Allergy And Infectious Diseases
Curated by ChEMBL
Affinity DataIC50: >3.80E+5nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair