BDBM50260945 CHEMBL496713::ethyl 4-(3-(2-aminoquinazolin-6-yl)-4-methyl-2-oxopyridin-1(2H)-yl)benzoate

SMILES CCOC(=O)c1ccc(cc1)-n1ccc(C)c(-c2ccc3nc(N)ncc3c2)c1=O

InChI Key InChIKey=JZTVWMNQNFKFGJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50260945   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260945(CHEMBL496713 | ethyl 4-(3-(2-aminoquinazolin-6-yl)...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of KDR (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260945(CHEMBL496713 | ethyl 4-(3-(2-aminoquinazolin-6-yl)...)
Affinity DataIC50:  17nMAssay Description:Inhibition of c-Kit (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260945(CHEMBL496713 | ethyl 4-(3-(2-aminoquinazolin-6-yl)...)
Affinity DataIC50:  68nMAssay Description:Inhibition of SCF-induced phosphorylation of c-Kit (unknown origin) in MO7e cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260945(CHEMBL496713 | ethyl 4-(3-(2-aminoquinazolin-6-yl)...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Src (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260945(CHEMBL496713 | ethyl 4-(3-(2-aminoquinazolin-6-yl)...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Lck (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed