BDBM50275436 CHEMBL4128250

SMILES COc1ccc(CCC(=O)N([C@@H]2CCCNC2)c2nccc3ccccc23)cc1

InChI Key InChIKey=OKTGXQMSOIQCTJ-HXUWFJFHSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50275436   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to human ERG by dofetilide fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PCSK9 expressed in CHO-K1 cells assessed as alkaline phosphatase secretion incubated overnight and measured after 3 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human C-terminal V5 epitope tagged PCSK9 by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human recombinant full length ProLabel-tagged PCSK9 expressed in CHO-K1 cells incubated overnight and measured after 3 days by chemilum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human recombinant full length ProLabel-tagged PCSK9 expressed in CHO-K1 cells incubated overnight and measured after 3 days by HTS assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed