BDBM50275436 CHEMBL4128250
SMILES COc1ccc(CCC(=O)N([C@@H]2CCCNC2)c2nccc3ccccc23)cc1
InChI Key InChIKey=OKTGXQMSOIQCTJ-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50275436
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:Binding affinity to human ERG by dofetilide fluorescence polarization binding assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PCSK9 expressed in CHO-K1 cells assessed as alkaline phosphatase secretion incubated overnight and measured after 3 d...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human C-terminal V5 epitope tagged PCSK9 by luciferase reporter assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human recombinant full length ProLabel-tagged PCSK9 expressed in CHO-K1 cells incubated overnight and measured after 3 days by chemilum...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human recombinant full length ProLabel-tagged PCSK9 expressed in CHO-K1 cells incubated overnight and measured after 3 days by HTS assa...More data for this Ligand-Target Pair