BDBM50300196 10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6.1.0^{2,7}.0^{14,18}]octadeca-1(18),2(7),3,5,11,14,16-heptaen-9-one::CHEMBL584052::atropisomer 1::atropisomer 2
SMILES Oc1ccc(cc1)C1c2c[nH]c3nccc(-c4ccccc4NC1=O)c23
InChI Key InChIKey=LGIBDQRYOFBMTC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50300196
Affinity DataKi: 0.00100nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of ALKChecked by AuthorMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 190nMAssay Description:Inhibition of cKitChecked by AuthorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 340nMAssay Description:Inhibition of GCKChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of JAK3 in human HT2 cells assessed as inhibition of IL2-induced STAT5 phosphorylation by flow cytometryChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as inhibition of GMCSF-induced STAT5 phosphorylation by flow cytometryChecked by AuthorMore data for this Ligand-Target Pair