BDBM50305819 1-(4-(thiophen-3-yl)benzyl)-5-(trifluoromethoxy)indoline-2,3-dione::CHEMBL603445::cid_45281797

SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccsc3)C(=O)C(=O)c2c1

InChI Key InChIKey=RSEUVMGVNMLOCQ-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50305819   

TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305819(1-(4-(thiophen-3-yl)benzyl)-5-(trifluoromethoxy)in...)
Affinity DataEC50: >442nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMuscarinic acetylcholine receptor M1(RAT)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305819(1-(4-(thiophen-3-yl)benzyl)-5-(trifluoromethoxy)in...)
Affinity DataEC50:  1.19E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305819(1-(4-(thiophen-3-yl)benzyl)-5-(trifluoromethoxy)in...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305819(1-(4-(thiophen-3-yl)benzyl)-5-(trifluoromethoxy)in...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup 3 secretory phospholipase A2(Homo sapiens)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50305819(1-(4-(thiophen-3-yl)benzyl)-5-(trifluoromethoxy)in...)
Affinity DataIC50:  2.55E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay