BDBM50345579 5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenylcarbamoyl)-2-methylphenyl)ethynyl)-N,1-dimethyl-1H-imidazole-2-carboxamide::CHEMBL1784637

SMILES CNC(=O)c1ncc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(c2)C(F)(F)F)n1C

InChI Key InChIKey=SUXYGJZMCWKJJI-UHFFFAOYSA-N

Data  30 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50345579   

TargetInsulin receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human IR using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human VEGFR3 using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human CDK2/Cyclin E using Histone H1 substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BRAF using MEK1 (K97R), ATP substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human Aurora A using H-LRRASLG peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human c-Kit using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human c-Met using KKKSPGEYVNIEFG peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  736nMAssay Description:Inhibition of human EGFR using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human EPHA2 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 3(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human EPHA3 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 7(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human EPHA7 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human FGFR2 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human FGFR3 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human FGFR4 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human VEGFR1 using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human VEGFR2 using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  536nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  58nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human PDGFRbeta using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human RET using KKKSPGEYVNIEFG by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human Tie2/TEK using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human Src using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: <0.150nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed