BDBM50366597 2-Acetylfuranonaphthoquinone::BBI-608::Napabucasin

SMILES CC(=O)c1cc2c(o1)C(=O)c1ccccc1C2=O

InChI Key InChIKey=DPHUWDIXHNQOSY-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50366597   

TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Westphalian Wilhelms University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Westphalian Wilhelms University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells assessed as reduction in ratio of phosphorylated STAT3 to total STAT3 level aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50:  425nMAssay Description:Inhibition of ALDH1A1 in human drug-tolerant MDA-MB-231/lapatinib cells assessed as after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Westphalian Wilhelms University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK293 cells expressing SIE-luc2P preincubated for overnight followed by IL-6 stim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Westphalian Wilhelms University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of IL-6 induced STAT3 phosphorylation at Tyr705 residue in human MCF7 cells preincubated for 1 hr followed by IL-6 stimulation and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed