BDBM50427452 CHEMBL2326941
SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12
InChI Key InChIKey=DNDNLFXKQSTINI-WUFINQPMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50427452
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 501nMAssay Description:Inhibition of full length human recombinant PDE10A using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of full length human recombinant PDE11A4 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of full length human recombinant PDE1B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of full length human recombinant PDE2A3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of full length human recombinant PDE9A3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of full length human recombinant PDE8B using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of full length human recombinant PDE7A1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of full length human recombinant PDE5A1 using [3H]-cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 0.631nMAssay Description:Inhibition of full length human recombinant PDE4D3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 0.631nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Mercachem
Curated by ChEMBL
Mercachem
Curated by ChEMBL
Affinity DataIC50: 0.501nMAssay Description:Inhibition of full length human recombinant PDE4B2 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair