BDBM50427452 CHEMBL2326941

SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key InChIKey=DNDNLFXKQSTINI-WUFINQPMSA-N

Data  6 KI  14 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50427452   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  501nMAssay Description:Inhibition of full length human recombinant PDE10A using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of full length human recombinant PDE11A4 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of full length human recombinant PDE1B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of full length human recombinant PDE2A3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  4nMAssay Description:Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of full length human recombinant PDE9A3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of full length human recombinant PDE8B using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of full length human recombinant PDE7A1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of full length human recombinant PDE5A1 using [3H]-cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of full length human recombinant PDE4D3 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of full length human recombinant PDE4B2 using [3H]-cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair