BDBM50428286 DABRAFENIB::GSK2118436A

SMILES CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F

InChI Key InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N

Data  25 IC50  4 EC50

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428286   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  4nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by Western blot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair