BDBM50428286 DABRAFENIB::GSK2118436A

SMILES CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F

InChI Key InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N

Data  25 IC50  4 EC50

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50428286   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  6nMAssay Description:Competitive binding affinity to BRAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  11nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as inhibition of ERK phosphorylation measured after 72 hrs by ELISA assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of wild type BRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase A-Raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  26nMAssay Description:Competitive binding affinity to ARAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  150nMAssay Description:Competitive binding affinity to CRAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank