BDBM50503631 CHEMBL4436792

SMILES N\C(=N/O)c1cccc(\C=C\c2ccnc(c2)-c2cc(F)ccc2O)c1

InChI Key InChIKey=AJXYGYQSEVLLRJ-SNAWJCMRSA-N

Data  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50503631   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50:  283nMAssay Description:Inhibition of full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 peptide as substrate after 30 mins by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MAO-A (unknown origin) using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate by MAO-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataKd:  1nMAssay Description:Binding affinity to full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) assessed as dissociation rate constant by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MAO-B (unknown origin) using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate by MAO-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50:  280nMAssay Description:Inhibition of human LSD1 (unknown orgin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50:  283nMAssay Description:Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50503631(CHEMBL4436792)
Affinity DataIC50:  283nMAssay Description:Inhibition of recombinant LSD1 (157 to 852 residues) (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 as substrate by amplex re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed