BDBM50506263 CHEMBL4465054::US11401295, Compound 2',3'-cGAMP
SMILES [H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12
InChI Key InChIKey=XRILCFTWUCUKJR-INFSMZHSSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50506263
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Affinity DataKd: <0.0100nMAssay Description:Binding affinity to wild type mouse STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 1.37E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataKd: 3.79nMAssay Description:Binding affinity to wild type human STING (139 to 379 residues) by ITC assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 3.86E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of anti 6His antibody-labeled terbium cryptate binding to human wild-type full-length 6His-tagged d2-labeled STING measured after 4 hrs by...More data for this Ligand-Target Pair
TargetInterferon regulatory factor 3(Homo sapiens)
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of IRF3 pathway in STING knockout human THP1 cells measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.88E+4nMAssay Description:Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 7.20E+3nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of IRF pathway incubated for 48 hrs by lu...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 3.91E+4nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 1.96E+4nMAssay Description:Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [140-379](Homo sapiens (Human))
Shanghai Jemincare Pharmaceuticals
US Patent
Shanghai Jemincare Pharmaceuticals
US Patent
Affinity DataIC50: 6.66E+3nMAssay Description:Fluorescence polarization assay (FP assay) was used to detect the affinity of compounds for human STING proteins. There were a certain amount of fluo...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 5.80nMAssay Description:Binding affinity to 6His-tagged human STING measured after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Binding affinity to human STING incubated for 60 mins measured by competitive TR-FRET assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataKd: 3.79E+3nMAssay Description:Agonist activity at wild type human STING C-terminal domain (139 to 379 residues) assessed as dissociation constant by isothermal titration calorimet...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 1.96E+4nMAssay Description:Agonist activity at STING (unknown origin)More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Agonist activity at human wild type STING expressed in 293T cells by digitonin cell based assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 2.84E+4nMAssay Description:Agonist activity at human wild type full length STING expressed in 293T cells incubated for 7 hrs by luciferase/cell based assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataKd: 6.20nMAssay Description:Binding affinity to wild type human STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair