BDBM50506263 CHEMBL4465054::US11401295, Compound 2',3'-cGAMP

SMILES [H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12

InChI Key InChIKey=XRILCFTWUCUKJR-INFSMZHSSA-N

Data  3 IC50  4 Kd  17 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50506263   

TargetStimulator of interferon genes protein(Mus musculus)
Merck

Curated by ChEMBL
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd: <0.0100nMAssay Description:Binding affinity to wild type mouse STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  3.79nMAssay Description:Binding affinity to wild type human STING (139 to 379 residues) by ITC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  3.79E+3nMAssay Description:Agonist activity at wild type human STING C-terminal domain (139 to 379 residues) assessed as dissociation constant by isothermal titration calorimet...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to wild type human STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails PubMed