BDBM50528541 CHEMBL4437631

SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1

InChI Key InChIKey=ZXPUKEPQYKBOHH-JOCHJYFZSA-N

Data  10 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50528541   

TargetNT-3 growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  790nMAssay Description:Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to wild-type human partial length DDR1 (R565 to V876 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  933nMAssay Description:Inhibition of human DDR2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of human ABL1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of human PDGFRBMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of human KITMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  15nMAssay Description:Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  933nMAssay Description:Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528541(CHEMBL4437631)
Affinity DataIC50:  790nMAssay Description:Inhibition of human TrkCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed